HintikkaXO is a multiomics dataset from a rat experiment studying effect of fat and prebiotics in diet. It contains high-throughput profiling data from 40 rat samples, including 39 biomarkers, 38 metabolites (NMR), and 12706 OTUs from 318 species, measured from Cecum. This is diet comparison study with High/Low fat diet and xylo-oligosaccaride supplementation. Column metadata is common for all experiments (microbiota, metabolites, biomarkers) and is described below.
data(HintikkaXOData)A MultiAssayExperiment with 3 experiments (microbiota, metabolites and biomarkers). rowData of the microbiota experiment contains taxonomic information at Phylum, Class, Order, Family, Genus, Species and OTU levels. The metabolites and biomarkers experiments contain 38 NMR metabolites and 39 biomarkers, respectively. The colData includes:
Sample ID (character)
Rat ID (factor)
Site of measurement ("Cecum"); single value
Diet group (factor; combination of the Fat and XOS fields)
Fat in Diet (factor; Low/High)
XOS Diet Supplement (numeric; 0/1)
Hintikka L et al. (2021): Xylo-oligosaccharides in prevention of hepatic steatosis and adipose tissue inflammation: associating taxonomic and metabolomic patterns in fecal microbiota with biclustering. International Journal of Environmental Research and Public Health 18(8):4049. https://doi.org/10.3390/ijerph18084049