Orchestrating Microbiome Analysis

Overview

Package: OMA
Authors:
- Leo Lahti [aut]
- Tuomas Borman [aut, cre]
- Felix GM Ernst [aut]
- and others (see the full list of contributors) [ctb]
Compiled: 2024-05-30
Package version: 0.98.21
R version: R version 4.4.0 (2024-04-24)
BioC version: 3.20
License: CC BY-NC-SA 4.0

Welcome

Important!

This is a development version of the Orchestrating Microbiome Analysis with Bioconductor (Lahti et al. 2021) book from the the miaverse.

Lahti, Leo, Sudarshan Shetty, Felix M Ernst, et al. 2021. Orchestrating Microbiome Analysis with Bioconductor [Beta Version]. microbiome.github.io/oma/.

You are reading the online book, Orchestrating Microbiome Analysis with Bioconductor (Lahti et al. 2021), where we walk through common strategies and workflows in microbiome data science.

The book shows through concrete examples how you can take advantage of the latest developments in R/Bioconductor for the manipulation, analysis, and reproducible reporting of hierarchical and heterogeneous microbiome profiling data sets. The book was borne out of necessity, while updating microbiome analysis tools to work with Bioconductor classes that provide support for multi-modal data collections. Many of these techniques are generic and widely applicable in other contexts as well.

This work has been heavily influenced by other similar resources, in particular the Orchestrating Single-Cell Analysis with Bioconductor (Amezquita et al. 2020), phyloseq tutorials (Callahan et al. 2016) and microbiome tutorials (Shetty and Lahti 2019). This book extends these resources to teach the grammar of Bioconductor workflows in the context of microbiome data science. As such, it supports the adoption of general skills in the analysis of large, hierarchical, and multi-modal data collections. We focus on microbiome analysis tools, including entirely new, partially updated as well as previously established methods.

Amezquita, Robert, Aaron Lun, Stephanie Hicks, and Raphael Gottardo. 2020. Orchestrating Single-Cell Analysis with Bioconductor. Bioconductor. https://bioconductor.org/books/release/OSCA/.
Callahan, Ben J., Kris Sankaran, Julia A. Fukuyama, Paul J. McMurdie, and Susan P. Holmes. 2016. β€œBioconductor Workflow for Microbiome Data Analysis: From Raw Reads to Community Analyses [Version 2; Peer Review: 3 Approved].” F1000Research 5: 1492. https://doi.org/10.12688/f1000research.8986.2.
Shetty, Sudarshan, and Leo Lahti. 2019. β€œMicrobiome Data Science.” Journal of Biosciences 44: 115. https://doi.org/10.1007/s12038-019-9930-2.

This online resource and its associated ecosystem of microbiome data science tools are a result of a community-driven development process, and welcoming new contributors. Several individuals have contributed methods, workflows and improvements as acknowledged in the Introduction. You can find more information on how to find us online and join the developer community through the project homepage at microbiome.github.io. This online resource has been written in RMarkdown with the bookdown R package. The material is free to use with the Creative Commons Attribution-NonCommercial 3.0 License.

Docker image

A Docker image built from this repository is available here:

πŸ‘‰ ghcr.io/microbiome/oma 🐳

Get started now πŸŽ‰

You can get access to all the packages used in this book in < 1 minute, using this command in a terminal:

bash
docker run -it ghcr.io/microbiome/oma:devel R

RStudio Server

An RStudio Server instance can be initiated from the Docker image as follows:

bash
docker run \
    --volume <local_folder>:<destination_folder> \
    -e PASSWORD=OHCA \
    -p 8787:8787 \
    ghcr.io/microbiome/oma:devel

The initiated RStudio Server instance will be available at https://localhost:8787.

Session info

sessioninfo::session_info(
    installed.packages()[,"Package"], 
    include_base = TRUE
)
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##   collate  C
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##   tz       Etc/UTC
##   date     2024-05-30
##   pandoc   3.2 @ /usr/bin/ (via rmarkdown)
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##   graphlayouts               1.1.1       2024-03-09 [2] RSPM (R 4.4.0)
##   grDevices                * 4.4.0       2024-05-06 [3] local
##   grid                       4.4.0       2024-05-06 [3] local
##   gridExtra                  2.3         2017-09-09 [2] RSPM (R 4.4.0)
##   gridGraphics               0.5-1       2020-12-13 [2] RSPM (R 4.4.0)
##   gsEasy                     1.5         2024-02-20 [2] RSPM (R 4.4.0)
##   gsl                        2.1-8       2023-01-24 [2] RSPM (R 4.4.0)
##   gss                        2.2-7       2023-08-16 [2] RSPM (R 4.4.0)
##   gtable                     0.3.5       2024-04-22 [2] RSPM (R 4.4.0)
##   gtools                     3.9.5       2023-11-20 [2] RSPM (R 4.4.0)
##   GUniFrac                   1.8         2023-09-14 [2] RSPM (R 4.4.0)
##   hardhat                    1.3.1       2024-02-02 [2] RSPM (R 4.4.0)
##   hash                       2.2.6.3     2023-08-19 [2] RSPM (R 4.4.0)
##   haven                      2.5.4       2023-11-30 [2] RSPM (R 4.4.0)
##   heatmaply                  1.5.0       2023-10-06 [2] RSPM (R 4.4.0)
##   here                       1.0.1       2020-12-13 [2] RSPM (R 4.4.0)
##   highr                      0.11        2024-05-26 [2] RSPM (R 4.4.0)
##   Hmisc                      5.1-3       2024-05-28 [2] RSPM (R 4.4.0)
##   hms                        1.1.3       2023-03-21 [2] RSPM (R 4.4.0)
##   htmlTable                  2.4.2       2023-10-29 [2] RSPM (R 4.4.0)
##   htmltools                * 0.5.8.1     2024-04-04 [2] RSPM (R 4.4.0)
##   htmlwidgets                1.6.4       2023-12-06 [2] RSPM (R 4.4.0)
##   httpuv                     1.6.15      2024-03-26 [2] RSPM (R 4.4.0)
##   httr                       1.4.7       2023-08-15 [2] RSPM (R 4.4.0)
##   httr2                      1.0.1       2024-04-01 [2] RSPM (R 4.4.0)
##   huge                       1.3.5       2021-06-30 [2] RSPM (R 4.4.0)
##   hwriter                    1.3.2.1     2022-04-08 [2] RSPM (R 4.4.0)
##   ids                        1.0.1       2017-05-31 [2] RSPM (R 4.4.0)
##   igraph                     2.0.3       2024-03-13 [2] RSPM (R 4.4.0)
##   impute                     1.79.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   ini                        0.3.1       2018-05-20 [2] RSPM (R 4.4.0)
##   inline                     0.3.19      2021-05-31 [2] RSPM (R 4.4.0)
##   interp                     1.1-6       2024-01-26 [2] RSPM (R 4.4.0)
##   ipred                      0.9-14      2023-03-09 [2] RSPM (R 4.4.0)
##   IRanges                    2.39.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   irlba                      2.3.5.1     2022-10-03 [2] RSPM (R 4.4.0)
##   isoband                    0.2.7       2022-12-20 [2] RSPM (R 4.4.0)
##   iterators                  1.0.14      2022-02-05 [2] RSPM (R 4.4.0)
##   janeaustenr                1.0.0       2022-08-26 [2] RSPM (R 4.4.0)
##   jpeg                       0.1-10      2022-11-29 [2] RSPM (R 4.4.0)
##   jquerylib                  0.1.4       2021-04-26 [2] RSPM (R 4.4.0)
##   jsonlite                   1.8.8       2023-12-04 [2] RSPM (R 4.4.0)
##   kableExtra                 1.4.0       2024-01-24 [2] RSPM (R 4.4.0)
##   KEGGREST                   1.45.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   kernlab                    0.9-32      2023-01-31 [2] RSPM (R 4.4.0)
##   KernSmooth                 2.23-24     2024-05-17 [2] RSPM (R 4.4.0)
##   knitr                      1.46        2024-04-06 [2] RSPM (R 4.4.0)
##   labeling                   0.4.3       2023-08-29 [2] RSPM (R 4.4.0)
##   lambda.r                   1.2.4       2019-09-18 [2] RSPM (R 4.4.0)
##   lars                       1.3         2022-04-13 [2] RSPM (R 4.4.0)
##   latentcor                  2.0.1       2022-09-05 [2] RSPM (R 4.4.0)
##   later                      1.3.2       2023-12-06 [2] RSPM (R 4.4.0)
##   lattice                    0.22-6      2024-03-20 [3] CRAN (R 4.4.0)
##   latticeExtra               0.6-30      2022-07-04 [2] RSPM (R 4.4.0)
##   lava                       1.8.0       2024-03-05 [2] RSPM (R 4.4.0)
##   lavaan                     0.6-17      2023-12-20 [2] RSPM (R 4.4.0)
##   lazyeval                   0.2.2       2019-03-15 [2] RSPM (R 4.4.0)
##   leaps                      3.1         2020-01-16 [2] RSPM (R 4.4.0)
##   lifecycle                  1.0.4       2023-11-07 [2] RSPM (R 4.4.0)
##   limma                      3.61.1      2024-05-20 [2] Bioconductor 3.20 (R 4.4.0)
##   linprog                    0.9-4       2022-03-09 [2] RSPM (R 4.4.0)
##   listenv                    0.9.1       2024-01-29 [2] RSPM (R 4.4.0)
##   littler                    0.3.20      2024-03-23 [2] RSPM (R 4.4.0)
##   lme4                       1.1-35.3    2024-04-16 [2] RSPM (R 4.4.0)
##   lmerTest                   3.1-3       2020-10-23 [2] RSPM (R 4.4.0)
##   lmom                       3.0         2023-08-29 [2] RSPM (R 4.4.0)
##   locfit                     1.5-9.9     2024-03-01 [2] RSPM (R 4.4.0)
##   logging                    0.10-108    2019-07-14 [2] RSPM (R 4.4.0)
##   lpSolve                    5.6.20      2023-12-10 [2] RSPM (R 4.4.0)
##   lubridate                  1.9.3       2023-09-27 [2] RSPM (R 4.4.0)
##   Maaslin2                   1.19.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   magic                      1.6-1       2022-11-16 [2] RSPM (R 4.4.0)
##   magrittr                   2.0.3       2022-03-30 [2] RSPM (R 4.4.0)
##   MASS                       7.3-60.2    2024-05-06 [3] local
##   mathjaxr                   1.6-0       2022-02-28 [2] RSPM (R 4.4.0)
##   Matrix                     1.7-0       2024-03-22 [3] CRAN (R 4.4.0)
##   MatrixGenerics             1.17.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   MatrixModels               0.5-3       2023-11-06 [2] RSPM (R 4.4.0)
##   matrixStats                1.3.0       2024-04-11 [2] RSPM (R 4.4.0)
##   mclust                     6.1.1       2024-04-29 [2] RSPM (R 4.4.0)
##   mediation                  4.5.0       2019-10-08 [2] RSPM (R 4.4.0)
##   memoise                    2.0.1       2021-11-26 [2] RSPM (R 4.4.0)
##   metadat                    1.2-0       2022-04-06 [2] RSPM (R 4.4.0)
##   metafor                    4.6-0       2024-03-28 [2] RSPM (R 4.4.0)
##   metagenomeSeq              1.47.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   methods                  * 4.4.0       2024-05-06 [3] local
##   mgcv                       1.9-1       2023-12-21 [3] CRAN (R 4.4.0)
##   mia                        1.13.19     2024-05-30 [2] Github (microbiome/mia@9198263)
##   miaTime                    0.1.21      2024-05-30 [2] Github (microbiome/miaTime@9fe9771)
##   miaViz                     1.13.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   microbenchmark             1.4.10      2023-04-28 [2] RSPM (R 4.4.0)
##   microbiome                 1.27.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   microbiomeDataSets         1.13.0      2024-05-02 [2] Bioconductor 3.20 (R 4.4.0)
##   MicrobiomeStat             1.2         2024-04-01 [2] RSPM (R 4.4.0)
##   mikropml                   1.6.1       2023-08-21 [2] RSPM (R 4.4.0)
##   mime                       0.12        2021-09-28 [2] RSPM (R 4.4.0)
##   miniUI                     0.1.1.1     2018-05-18 [2] RSPM (R 4.4.0)
##   minqa                      1.2.7       2024-05-20 [2] RSPM (R 4.4.0)
##   mixedCCA                   1.6.2       2022-09-09 [2] RSPM (R 4.4.0)
##   MLeval                     0.3         2020-02-12 [2] RSPM (R 4.4.0)
##   MLmetrics                  1.1.3       2024-04-13 [2] RSPM (R 4.4.0)
##   MMUPHin                    1.19.1      2024-05-20 [2] Bioconductor 3.20 (R 4.4.0)
##   mnormt                     2.1.1       2022-09-26 [2] RSPM (R 4.4.0)
##   modeest                    2.4.0       2019-11-18 [2] RSPM (R 4.4.0)
##   ModelMetrics               1.2.2.2     2020-03-17 [2] RSPM (R 4.4.0)
##   modelr                     0.1.11      2023-03-22 [2] RSPM (R 4.4.0)
##   modeltools                 0.2-23      2020-03-05 [2] RSPM (R 4.4.0)
##   multcomp                   1.4-25      2023-06-20 [2] RSPM (R 4.4.0)
##   multcompView               0.1-10      2024-03-08 [2] RSPM (R 4.4.0)
##   MultiAssayExperiment       1.31.1      2024-05-03 [2] Bioconductor 3.20 (R 4.4.0)
##   multiview                  0.8         2023-03-31 [2] RSPM (R 4.4.0)
##   multtest                   2.61.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   munsell                    0.5.1       2024-04-01 [2] RSPM (R 4.4.0)
##   mvtnorm                    1.2-5       2024-05-21 [2] RSPM (R 4.4.0)
##   NADA                       1.6-1.1     2020-03-22 [2] RSPM (R 4.4.0)
##   NbClust                    3.0.1       2022-05-02 [2] RSPM (R 4.4.0)
##   NetCoMi                    1.1.0       2024-05-30 [2] Github (stefpeschel/NetCoMi@0809c7a)
##   nlme                       3.1-164     2023-11-27 [3] CRAN (R 4.4.0)
##   nloptr                     2.0.3       2022-05-26 [2] RSPM (R 4.4.0)
##   nnet                       7.3-19      2023-05-03 [3] CRAN (R 4.4.0)
##   nnls                       1.5         2023-09-11 [2] RSPM (R 4.4.0)
##   numDeriv                   2016.8-1.1  2019-06-06 [2] RSPM (R 4.4.0)
##   OMA                        0.98.21     2024-05-30 [1] Bioconductor
##   ontologyIndex              2.12        2024-02-27 [2] RSPM (R 4.4.0)
##   openssl                    2.2.0       2024-05-16 [2] RSPM (R 4.4.0)
##   optparse                   1.7.5       2024-04-16 [2] RSPM (R 4.4.0)
##   orca                       1.1-2       2023-12-13 [2] RSPM (R 4.4.0)
##   osqp                       0.6.3.2     2023-10-20 [2] RSPM (R 4.4.0)
##   parallel                   4.4.0       2024-05-06 [3] local
##   parallelly                 1.37.1      2024-02-29 [2] RSPM (R 4.4.0)
##   patchwork                  1.2.0       2024-01-08 [2] RSPM (R 4.4.0)
##   pbapply                    1.7-2       2023-06-27 [2] RSPM (R 4.4.0)
##   pbivnorm                   0.6.0       2015-01-23 [2] RSPM (R 4.4.0)
##   pbkrtest                   0.5.2       2023-01-19 [2] RSPM (R 4.4.0)
##   pcaPP                      2.0-4       2023-12-07 [2] RSPM (R 4.4.0)
##   permute                    0.9-7       2022-01-27 [2] RSPM (R 4.4.0)
##   pheatmap                   1.0.12      2019-01-04 [2] RSPM (R 4.4.0)
##   phyloseq                   1.49.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   pillar                     1.9.0       2023-03-22 [2] RSPM (R 4.4.0)
##   pixmap                     0.4-13      2024-05-03 [2] RSPM (R 4.4.0)
##   pkgbuild                   1.4.4       2024-03-17 [2] RSPM (R 4.4.0)
##   pkgconfig                  2.0.3       2019-09-22 [2] RSPM (R 4.4.0)
##   pkgdown                    2.0.9       2024-04-18 [2] RSPM (R 4.4.0)
##   pkgload                    1.3.4       2024-01-16 [2] RSPM (R 4.4.0)
##   plogr                      0.2.0       2018-03-25 [2] RSPM (R 4.4.0)
##   plotly                     4.10.4      2024-01-13 [2] RSPM (R 4.4.0)
##   pls                        2.8-3       2023-11-17 [2] RSPM (R 4.4.0)
##   plyr                       1.8.9       2023-10-02 [2] RSPM (R 4.4.0)
##   png                        0.1-8       2022-11-29 [2] RSPM (R 4.4.0)
##   polyclip                   1.10-6      2023-09-27 [2] RSPM (R 4.4.0)
##   polynom                    1.4-1       2022-04-11 [2] RSPM (R 4.4.0)
##   posterior                  1.5.0       2023-10-31 [2] RSPM (R 4.4.0)
##   prabclus                   2.3-3       2023-10-24 [2] RSPM (R 4.4.0)
##   praise                     1.0.0       2015-08-11 [2] RSPM (R 4.4.0)
##   preprocessCore             1.67.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   prettyunits                1.2.0       2023-09-24 [2] RSPM (R 4.4.0)
##   pROC                       1.18.5      2023-11-01 [2] RSPM (R 4.4.0)
##   processx                   3.8.4       2024-03-16 [2] RSPM (R 4.4.0)
##   prodlim                    2023.08.28  2023-08-28 [2] RSPM (R 4.4.0)
##   profvis                    0.3.8       2023-05-02 [2] RSPM (R 4.4.0)
##   progress                   1.2.3       2023-12-06 [2] RSPM (R 4.4.0)
##   progressr                  0.14.0      2023-08-10 [2] RSPM (R 4.4.0)
##   promises                   1.3.0       2024-04-05 [2] RSPM (R 4.4.0)
##   proxy                      0.4-27      2022-06-09 [2] RSPM (R 4.4.0)
##   ps                         1.7.6       2024-01-18 [2] RSPM (R 4.4.0)
##   pscl                       1.5.9       2024-01-31 [2] RSPM (R 4.4.0)
##   psych                      2.4.3       2024-03-18 [2] RSPM (R 4.4.0)
##   pulsar                     0.3.11      2023-09-24 [2] RSPM (R 4.4.0)
##   purrr                      1.0.2       2023-08-10 [2] RSPM (R 4.4.0)
##   pwalign                    1.1.0       2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   qap                        0.1-2       2022-06-27 [2] RSPM (R 4.4.0)
##   qgraph                     1.9.8       2023-11-03 [2] RSPM (R 4.4.0)
##   quadprog                   1.5-8       2019-11-20 [2] RSPM (R 4.4.0)
##   quantreg                   5.98        2024-05-26 [2] RSPM (R 4.4.0)
##   quarto                     1.4         2024-03-06 [2] RSPM (R 4.4.0)
##   R6                         2.5.1       2021-08-19 [2] RSPM (R 4.4.0)
##   ragg                       1.3.2       2024-05-15 [2] RSPM (R 4.4.0)
##   randomcoloR                1.1.0.1     2019-11-24 [2] RSPM (R 4.4.0)
##   randomForest               4.7-1.1     2022-05-23 [2] RSPM (R 4.4.0)
##   rappdirs                   0.3.3       2021-01-31 [2] RSPM (R 4.4.0)
##   rbibutils                  2.2.16      2023-10-25 [2] RSPM (R 4.4.0)
##   rcmdcheck                  1.4.0       2021-09-27 [2] RSPM (R 4.4.0)
##   RColorBrewer               1.1-3       2022-04-03 [2] RSPM (R 4.4.0)
##   Rcpp                       1.0.12      2024-01-09 [2] RSPM (R 4.4.0)
##   RcppAnnoy                  0.0.22      2024-01-23 [2] RSPM (R 4.4.0)
##   RcppArmadillo              0.12.8.3.0  2024-05-08 [2] RSPM (R 4.4.0)
##   RcppEigen                  0.3.4.0.0   2024-02-28 [2] RSPM (R 4.4.0)
##   RcppGSL                    0.3.13      2023-01-13 [2] RSPM (R 4.4.0)
##   RcppHNSW                   0.6.0       2024-02-04 [2] RSPM (R 4.4.0)
##   RcppML                     0.3.7       2021-09-21 [2] RSPM (R 4.4.0)
##   RcppNumerical              0.6-0       2023-09-06 [2] RSPM (R 4.4.0)
##   RcppParallel               5.1.7       2023-02-27 [2] RSPM (R 4.4.0)
##   RcppProgress               0.4.2       2020-02-06 [2] RSPM (R 4.4.0)
##   RcppTOML                   0.2.2       2023-01-29 [2] RSPM (R 4.4.0)
##   RcppZiggurat               0.1.6       2020-10-20 [2] RSPM (R 4.4.0)
##   Rdpack                     2.6         2023-11-08 [2] RSPM (R 4.4.0)
##   readr                      2.1.5       2024-01-10 [2] RSPM (R 4.4.0)
##   readxl                     1.4.3       2023-07-06 [2] RSPM (R 4.4.0)
##   rebook                     1.15.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   recipes                    1.0.10      2024-02-18 [2] RSPM (R 4.4.0)
##   registry                   0.5-1       2019-03-05 [2] RSPM (R 4.4.0)
##   rematch                    2.0.0       2023-08-30 [2] RSPM (R 4.4.0)
##   rematch2                   2.1.2       2020-05-01 [2] RSPM (R 4.4.0)
##   remotes                    2.5.0       2024-03-17 [2] RSPM (R 4.4.0)
##   renv                       1.0.7       2024-04-11 [2] RSPM (R 4.4.0)
##   reprex                     2.1.0       2024-01-11 [2] RSPM (R 4.4.0)
##   reshape2                   1.4.4       2020-04-09 [2] RSPM (R 4.4.0)
##   reticulate                 1.37.0      2024-05-21 [2] RSPM (R 4.4.0)
##   Rfast                      2.1.0       2023-11-09 [2] RSPM (R 4.4.0)
##   rgl                        1.3.1       2024-03-05 [2] RSPM (R 4.4.0)
##   rhdf5                      2.49.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   rhdf5filters               1.17.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   Rhdf5lib                   1.27.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   Rhtslib                    3.1.0       2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   rjson                      0.2.21      2022-01-09 [2] RSPM (R 4.4.0)
##   rlang                      1.1.3       2024-01-10 [2] RSPM (R 4.4.0)
##   rmarkdown                  2.27        2024-05-17 [2] RSPM (R 4.4.0)
##   Rmpfr                      0.9-5       2024-01-21 [2] RSPM (R 4.4.0)
##   rmutil                     1.1.10      2022-10-27 [2] RSPM (R 4.4.0)
##   rngtools                   1.5.2       2021-09-20 [2] RSPM (R 4.4.0)
##   robustbase                 0.99-2      2024-01-27 [2] RSPM (R 4.4.0)
##   ROCR                       1.0-11      2020-05-02 [2] RSPM (R 4.4.0)
##   rootSolve                  1.8.2.4     2023-09-21 [2] RSPM (R 4.4.0)
##   roxygen2                   7.3.1       2024-01-22 [2] RSPM (R 4.4.0)
##   rpart                      4.1.23      2023-12-05 [3] CRAN (R 4.4.0)
##   rprojroot                  2.0.4       2023-11-05 [2] RSPM (R 4.4.0)
##   Rsamtools                  2.21.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   RSpectra                   0.16-1      2022-04-24 [2] RSPM (R 4.4.0)
##   RSQLite                    2.3.7       2024-05-27 [2] RSPM (R 4.4.0)
##   rstatix                    0.7.2       2023-02-01 [2] RSPM (R 4.4.0)
##   rstudioapi                 0.16.0      2024-03-24 [2] RSPM (R 4.4.0)
##   rsvd                       1.0.5       2021-04-16 [2] RSPM (R 4.4.0)
##   Rtsne                      0.17        2023-12-07 [2] RSPM (R 4.4.0)
##   rversions                  2.1.2       2022-08-31 [2] RSPM (R 4.4.0)
##   rvest                      1.0.4       2024-02-12 [2] RSPM (R 4.4.0)
##   S4Arrays                   1.5.1       2024-05-20 [2] Bioconductor 3.20 (R 4.4.0)
##   S4Vectors                  0.43.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   sandwich                   3.1-0       2023-12-11 [2] RSPM (R 4.4.0)
##   sass                       0.4.9       2024-03-15 [2] RSPM (R 4.4.0)
##   ScaledMatrix               1.13.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   scales                     1.3.0       2023-11-28 [2] RSPM (R 4.4.0)
##   scater                     1.33.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   scatterplot3d              0.3-44      2023-05-05 [2] RSPM (R 4.4.0)
##   scs                        3.2.4       2023-04-11 [2] RSPM (R 4.4.0)
##   scuttle                    1.15.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   sechm                      1.13.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   selectr                    0.4-2       2019-11-20 [2] RSPM (R 4.4.0)
##   seriation                  1.5.5       2024-04-17 [2] RSPM (R 4.4.0)
##   sessioninfo                1.2.2       2021-12-06 [2] RSPM (R 4.4.0)
##   shape                      1.4.6.1     2024-02-23 [2] RSPM (R 4.4.0)
##   shiny                      1.8.1.1     2024-04-02 [2] RSPM (R 4.4.0)
##   ShortRead                  1.63.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   SingleCellExperiment       1.27.2      2024-05-24 [2] Bioconductor 3.20 (R 4.4.0)
##   sitmo                      2.0.2       2021-10-13 [2] RSPM (R 4.4.0)
##   sn                         2.1.1       2023-04-04 [2] RSPM (R 4.4.0)
##   snow                       0.4-4       2021-10-27 [2] RSPM (R 4.4.0)
##   SnowballC                  0.7.1       2023-04-25 [2] RSPM (R 4.4.0)
##   som                        0.3-5.1     2016-07-06 [2] RSPM (R 4.4.0)
##   sourcetools                0.1.7-1     2023-02-01 [2] RSPM (R 4.4.0)
##   sp                         2.1-4       2024-04-30 [2] RSPM (R 4.4.0)
##   SparseArray                1.5.7       2024-05-24 [2] Bioconductor 3.20 (R 4.4.0)
##   SparseM                    1.82        2024-05-27 [2] RSPM (R 4.4.0)
##   sparseMatrixStats          1.17.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   spatial                    7.3-17      2023-07-20 [3] CRAN (R 4.4.0)
##   SpiecEasi                  1.1.3       2024-05-30 [2] Github (zdk123/SpiecEasi@5f396da)
##   splines                    4.4.0       2024-05-06 [3] local
##   SPRING                     1.0.4       2024-05-30 [2] Github (GraceYoon/SPRING@3d641a4)
##   SQUAREM                    2021.1      2021-01-13 [2] RSPM (R 4.4.0)
##   stable                     1.1.6       2022-03-02 [2] RSPM (R 4.4.0)
##   stabledist                 0.7-1       2016-09-12 [2] RSPM (R 4.4.0)
##   statip                     0.2.3       2019-11-17 [2] RSPM (R 4.4.0)
##   statmod                    1.5.0       2023-01-06 [2] RSPM (R 4.4.0)
##   stats                    * 4.4.0       2024-05-06 [3] local
##   stats4                     4.4.0       2024-05-06 [3] local
##   stringdist                 0.9.12      2023-11-28 [2] RSPM (R 4.4.0)
##   stringi                    1.8.4       2024-05-06 [2] RSPM (R 4.4.0)
##   stringr                    1.5.1       2023-11-14 [2] RSPM (R 4.4.0)
##   SummarizedExperiment       1.35.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   SuperLearner               2.0-29      2024-02-20 [2] RSPM (R 4.4.0)
##   survival                   3.6-4       2024-04-24 [2] RSPM (R 4.4.0)
##   svglite                    2.1.3       2023-12-08 [2] RSPM (R 4.4.0)
##   svUnit                     1.0.6       2021-04-19 [2] RSPM (R 4.4.0)
##   sys                        3.4.2       2023-05-23 [2] RSPM (R 4.4.0)
##   systemfonts                1.1.0       2024-05-15 [2] RSPM (R 4.4.0)
##   tcltk                      4.4.0       2024-05-06 [3] local
##   tensorA                    0.36.2.1    2023-12-13 [2] RSPM (R 4.4.0)
##   testthat                   3.2.1.1     2024-04-14 [2] RSPM (R 4.4.0)
##   textshaping                0.4.0       2024-05-24 [2] RSPM (R 4.4.0)
##   TH.data                    1.1-2       2023-04-17 [2] RSPM (R 4.4.0)
##   tibble                     3.2.1       2023-03-20 [2] RSPM (R 4.4.0)
##   tidybayes                  3.0.6       2023-08-12 [2] RSPM (R 4.4.0)
##   tidygraph                  1.3.1       2024-01-30 [2] RSPM (R 4.4.0)
##   tidyr                      1.3.1       2024-01-24 [2] RSPM (R 4.4.0)
##   tidyselect                 1.2.1       2024-03-11 [2] RSPM (R 4.4.0)
##   tidytext                   0.4.2       2024-04-10 [2] RSPM (R 4.4.0)
##   tidytree                   0.4.6       2023-12-12 [2] RSPM (R 4.4.0)
##   tidyverse                  2.0.0       2023-02-22 [2] RSPM (R 4.4.0)
##   timechange                 0.3.0       2024-01-18 [2] RSPM (R 4.4.0)
##   timeDate                   4032.109    2023-12-14 [2] RSPM (R 4.4.0)
##   timeSeries                 4032.109    2024-01-14 [2] RSPM (R 4.4.0)
##   tinytex                    0.51        2024-05-06 [2] RSPM (R 4.4.0)
##   TMB                        1.9.11      2024-04-03 [2] RSPM (R 4.4.0)
##   tokenizers                 0.3.0       2022-12-22 [2] RSPM (R 4.4.0)
##   tools                      4.4.0       2024-05-06 [3] local
##   topGO                      2.57.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   treeio                     1.29.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   TreeSummarizedExperiment   2.13.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   truncnorm                  1.0-9       2023-03-20 [2] RSPM (R 4.4.0)
##   TSP                        1.2-4       2023-04-04 [2] RSPM (R 4.4.0)
##   tweedie                    2.3.5       2022-08-17 [2] RSPM (R 4.4.0)
##   tweenr                     2.0.3       2024-02-26 [2] RSPM (R 4.4.0)
##   tzdb                       0.4.0       2023-05-12 [2] RSPM (R 4.4.0)
##   UCSC.utils                 1.1.0       2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   urlchecker                 1.0.1       2021-11-30 [2] RSPM (R 4.4.0)
##   usethis                    2.2.3       2024-02-19 [2] RSPM (R 4.4.0)
##   utf8                       1.2.4       2023-10-22 [2] RSPM (R 4.4.0)
##   utils                    * 4.4.0       2024-05-06 [3] local
##   uuid                       1.2-0       2024-01-14 [2] RSPM (R 4.4.0)
##   uwot                       0.2.2       2024-04-21 [2] RSPM (R 4.4.0)
##   V8                         4.4.2       2024-02-15 [2] RSPM (R 4.4.0)
##   vctrs                      0.6.5       2023-12-01 [2] RSPM (R 4.4.0)
##   vegan                      2.6-6.1     2024-05-21 [2] RSPM (R 4.4.0)
##   VGAM                       1.1-11      2024-05-15 [2] RSPM (R 4.4.0)
##   vipor                      0.4.7       2023-12-18 [2] RSPM (R 4.4.0)
##   viridis                    0.6.5       2024-01-29 [2] RSPM (R 4.4.0)
##   viridisLite                0.4.2       2023-05-02 [2] RSPM (R 4.4.0)
##   vroom                      1.6.5       2023-12-05 [2] RSPM (R 4.4.0)
##   waldo                      0.5.2       2023-11-02 [2] RSPM (R 4.4.0)
##   webshot                    0.5.5       2023-06-26 [2] RSPM (R 4.4.0)
##   WGCNA                      1.72-5      2023-12-07 [2] RSPM (R 4.4.0)
##   whisker                    0.4.1       2022-12-05 [2] RSPM (R 4.4.0)
##   withr                      3.0.0       2024-01-16 [2] RSPM (R 4.4.0)
##   Wrench                     1.23.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   xfun                       0.44        2024-05-15 [2] RSPM (R 4.4.0)
##   xgboost                    1.7.7.1     2024-01-25 [2] RSPM (R 4.4.0)
##   XML                        3.99-0.16.1 2024-01-22 [2] RSPM (R 4.4.0)
##   xml2                       1.3.6       2023-12-04 [2] RSPM (R 4.4.0)
##   xopen                      1.0.1       2024-04-25 [2] RSPM (R 4.4.0)
##   xtable                     1.8-4       2019-04-21 [2] RSPM (R 4.4.0)
##   XVector                    0.45.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   yaml                       2.3.8       2023-12-11 [2] RSPM (R 4.4.0)
##   yesno                      0.1.2       2020-07-10 [2] RSPM (R 4.4.0)
##   yulab.utils                0.1.4       2024-01-28 [2] RSPM (R 4.4.0)
##   zCompositions              1.5.0-3     2024-03-13 [2] RSPM (R 4.4.0)
##   zip                        2.3.1       2024-01-27 [2] RSPM (R 4.4.0)
##   zlibbioc                   1.51.0      2024-05-01 [2] Bioconductor 3.20 (R 4.4.0)
##   zoo                        1.8-12      2023-04-13 [2] RSPM (R 4.4.0)
##  
##   [1] /tmp/RtmpyWQhp3/Rinstb2b8754a
##   [2] /usr/local/lib/R/site-library
##   [3] /usr/local/lib/R/library
##  
##  ─ Python configuration ────────────────────────────────────────────────────
##   Python is not available
##  
##  ───────────────────────────────────────────────────────────────────────────
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